C++ – CWinApp http://cwinapp.com/ Tue, 28 Jun 2022 17:38:09 +0000 en-US hourly 1 https://wordpress.org/?v=5.9.3 https://cwinapp.com/wp-content/uploads/2021/10/icon-3-120x120.png C++ – CWinApp http://cwinapp.com/ 32 32 Richard C. Cumo, Canfield, Ohio Obituary https://cwinapp.com/richard-c-cumo-canfield-ohio-obituary/ Tue, 28 Jun 2022 17:35:42 +0000 https://cwinapp.com/richard-c-cumo-canfield-ohio-obituary/ CANFIELD, Ohio (MyValleyTributes) – Richard C. Cumo, 73 of Canfield, died early Friday morning, June 24, 2022. Richard was born on December 31, 1948 in New Castle, Pennsylvania, the son of the late Marion and Antoinette (Chicone) Cumo. Richard is a graduate of New Castle High School and was a UPS driver for 33 years […]]]>

CANFIELD, Ohio (MyValleyTributes) – Richard C. Cumo, 73 of Canfield, died early Friday morning, June 24, 2022.

Richard was born on December 31, 1948 in New Castle, Pennsylvania, the son of the late Marion and Antoinette (Chicone) Cumo.

Richard is a graduate of New Castle High School and was a UPS driver for 33 years before retiring in 2003.

Richard was a McDonald’s fanatic, loved their coffee and was well known at Canfield McDonald’s for his daily visits.

His wife, the former Leonajean Fortuna, whom he married on September 9, 1972, died on July 7, 2012.

He is survived by his two sons, Richard M. Cumo of Cleveland and Antony (Kelly) Cumo of Canfield and two grandchildren, Nathan and Ryan. Richard also leaves behind his sister, Angeline DeChellis of Struthers and a brother, Joseph Cumo of Canton.

Besides his parents and his wife, Richard was predeceased by a brother, Marion Cumo.

At Richard’s request, there will be no on-call hours or services.

Arrangements managed by Lane Family Funeral Homes.

To send flowers to Richard’s family, please visit our floral shop.

A television tribute will air on Wednesday, June 29 at the following approximate times: 6:43 a.m. on WYTV, 9:32 a.m. on WKBN, 10:58 a.m. on FOX, and 8:12 p.m. on MyYTV.

]]>
C-reactive protein levels predict risk of erectile dysfunction https://cwinapp.com/c-reactive-protein-levels-predict-risk-of-erectile-dysfunction/ Mon, 27 Jun 2022 08:59:00 +0000 https://cwinapp.com/c-reactive-protein-levels-predict-risk-of-erectile-dysfunction/ Erectile dysfunction (ED) is associated with negative effects on the physical and mental health of men, as well as the life satisfaction of their partners. Although men of any age can be diagnosed with erectile dysfunction, it is much more common in older men, especially those over 75. Worldwide, erectile dysfunction-related comorbidities are expected to […]]]>

Erectile dysfunction (ED) is associated with negative effects on the physical and mental health of men, as well as the life satisfaction of their partners. Although men of any age can be diagnosed with erectile dysfunction, it is much more common in older men, especially those over 75. Worldwide, erectile dysfunction-related comorbidities are expected to affect nearly 320 million men by 2025.

Study: New predictive risk factor for erectile dysfunction: high sensitivity serum C-reactive protein. Image Credit: Wasan Tita / Shutterstock.com

Background

Multiple factors contribute to the pathogenesis of erectile dysfunction. Vascular erectile dysfunction, for example, is related to vascular endothelial dysfunction and is associated with lower nitric oxide production and restricted blood flow which, taken together, inhibit erectile function. Thus, cardiovascular disease (CVD) is linked to ED.

C-reactive protein (CRP) is expressed in humans during the acute immune response. Moreover, high-sensitivity CRP (hs-CRP) is a sensitive biomarker of inflammation that can independently predict CVD in its early stages. It has been hypothesized that CRP is strongly associated with erectile dysfunction and that erectile dysfunction may indicate early phase CVD.

About the study

A recent meta-analysis published in Andrology aimed to describe the relationship between CRP and ED. This study followed the PRISMA statement (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Here, the researchers performed a systemic search of PubMed, Web of Science and Cochrane Library to identify relevant republished literature before January 1, 2022.

A total of 12 relevant articles were selected. These included nine studies comparing serum CRP levels in ER patients and controls, and three studies analyzing CRP levels in ER patients on phosphodiesterase 5 (PDE-5i) inhibitor therapy.

The nine studies comparing serum CRP levels in ED patients and controls included 1363 ED patients and 1400 healthy controls. The results showed significantly higher CRP levels in ED patients than in healthy controls, indicating higher levels of inflammation in ED patients.

Protective effect of PDE-5i therapy on CRP in ED patients

Previous evidence has shown that on-demand PDE-5i can improve erectile function, as well as cavernous endothelial function.

A comparative study of changes in ED patients and their CRP levels before and after PDE-5i treatment indicated that CRP levels decreased by 0.38 mg/l in ED patients after starting treatment. This decrease was greater in emergency patients who complied with the medication regimen.

In the present study, PDE-5is therapy was found to significantly reduce hs-CRP levels. This finding could expand current indications for erectile dysfunction risk assessment in asymptomatic patients, as well as those not considered at risk for erectile dysfunction.

The results suggest that hs-CRP levels can be used for general risk assessment of patients with ED, as they provide information about patients’ inflammatory risk profile. However, the mechanism responsible for this association remains unclear.

conclusion

The current meta-analysis is the first to investigate the relationship between CRP and ED. Taken together, the study results indicate that ED patients have significantly higher CRP levels than healthy individuals. Additionally, treatment with PDE-5i could significantly decrease serum CRP levels in patients with erectile dysfunction.

Journal reference:

  • Liu, G., Zhang, Y., Zhang, W., et al. (2022). New predictive risk factor for erectile dysfunction: high sensitivity serum C-reactive protein. Andrology. do I:10.1111/andr.13206.
]]>
New CBD Shop Opens in St. C. | News, Sports, Jobs https://cwinapp.com/new-cbd-shop-opens-in-st-c-news-sports-jobs/ Sun, 26 Jun 2022 00:33:43 +0000 https://cwinapp.com/new-cbd-shop-opens-in-st-c-news-sports-jobs/ TL Photo/CARRI GRAHAM Upscale CBD boutique owner Brian Phillips stands inside his newly opened store at 165 E. Main St., St. Clairsville. The store offers a range of CBD products, apparel, and gift items. ST. CLAIRSVILLE — The owner of a new CBD store that opened this week hopes the products […]]]>

TL Photo/CARRI GRAHAM Upscale CBD boutique owner Brian Phillips stands inside his newly opened store at 165 E. Main St., St. Clairsville. The store offers a range of CBD products, apparel, and gift items.

ST. CLAIRSVILLE — The owner of a new CBD store that opened this week hopes the products he sells will help ease customers’ ailments.

The High End CBD Shop held its grand opening Wednesday at 165 E. Main St. in St. Clairsville. Store owner Brian Phillips said he carries a bit of everything when it comes to CBD products, including gummies, oils, lotions and pain sticks, as well as others. gift items, apparel and more.

Phillips said her main goal is to help people struggling with pain or mental health issues. These people can benefit from taking CBD, he said.

“We love helping patients – patients who are in pain, patients who are suffering from anxiety, depression, etc. All of these things can be helped with CBD. These are things that I have myself, and I have a passion for trying to help people deal with these things,” he said.

Additionally, he said he hoped to help reduce the drug problem in the region by providing an alternative to illegal substances.

Phillips’ top priority is to help guide people to what’s best for their health, offering her expertise to anyone who needs help.

“If anyone has questions, concerns about CBD that they need answered and are looking for someone to ask, someone they can trust, they can come ask us. They don’t have anything to buy, I don’t care if they buy anything. If they need help, don’t hesitate to come and talk to us. he said.

“My main focus is people. I’m sick of seeing the same thing with all the CBD stores – in front they’re for the patient, and in the back they don’t care. It’s not us. This is what will differentiate us. »

The deciding factor in opening his business in St. Clairsville came after the response he received from city leaders. Phillips said he was warmly received by many officials.

“I had searched for several months trying to find a location and found this location about 3 months ago. I spoke to the planner, and they welcomed me to the city with open arms and were ready to go. This, for me, was extremely important. The mayor, the town planner, all were extremely helpful”, he said.

Once the business is set up, Phillips said he plans to give back to the community that took him in.

“I plan to do some benefit and fundraising for people with cancer and other illnesses,” he added.

The shop is also proud to sell locally owned Tho Bros Premium CBD. Phillips said they offer high-quality products at a lower cost. He said he was able to sell some products at half the cost as competitors, but the quality of the products remained excellent.

The High End CBD Shop is now open 10 a.m. to 7 p.m. Monday through Saturday. It is located next to Papa D’s Pizza. Phillips said he was working to hire another employee so he could extend the hours to include Sundays.



Today’s breaking news and more to your inbox







]]>
Donald C Chandler | The Bridgton News https://cwinapp.com/donald-c-chandler-the-bridgton-news/ Fri, 24 Jun 2022 17:08:06 +0000 https://cwinapp.com/donald-c-chandler-the-bridgton-news/ Donald Chandler Donald Carlisle Chandler Jr. died on the night of June 15, 2022 in the care of Bay Square Memory Care in Yarmouth with a terminal stage of Parkin-son’s illness. Son of Donald and Mary (Sweetser) Chandler of New Gloucester, Donnie was born March 13, 1936 in Portland Maine. He drove his first tractor […]]]>
Donald Chandler

Donald Carlisle Chandler Jr. died on the night of June 15, 2022 in the care of Bay Square Memory Care in Yarmouth with a terminal stage of Parkin-
son’s illness.

Son of Donald and Mary (Sweetser) Chandler of New Gloucester, Donnie was born March 13, 1936 in Portland Maine. He drove his first tractor in
the age of 12, when the tractors were delivered by rail. He graduated from New Gloucester High School in 1954 and joined The Oliver Stores in New Gloucester,
a branch opened by his father; he worked for The Oliver Stores for a total of eight years, including briefly at Farmington and finally at the North Fryeburg store.

Around 1962, Donnie opened the Lovell Village Garage (at the intersection of Routes 5 and 93), originally an auto repair shop and gas station, which became a central community gathering point for guys from the city to engage in storytelling, share and get the news and exchange opinions. Over time, Donnie moved on to working more and more on farm equipment, his true professional love. He has made many “field calls”, near and far, to help farmers with broken hay scoops and other equipment, and over the years he has become unique in his knowledge and skills. working on much of this equipment.

Donnie married Judie Sylvester (now DeMayo) in 1964, and in 1967 their daughter Susan (“Sue”) was born. After their marriage ended, Donnie met and in 1980 married Lynne (Gardner) Botty, and Donnie and Sue moved from Swain Road in Lovell to Corn Shop Road in Fryeburg.

Donnie was a longtime member of the Maine Antique Tractor Club and also ran the Tractor Show on Tuesdays at the Fryeburg Fair for many years. He participated in and won many blue ribbons at tractor shows at Fryeburg, Cumberland and other fairs. Not one for many vacations, Donnie and Lynne enjoyed traveling to farm equipment auctions and shows for professional and personal enjoyment, and made many friends along the way.

Although most people retire in their 60s, Donnie didn’t feel the need to. He closed the garage around 2010 and moved the business to the garage of his house where he continued his work until the spring of 2021. His work was his hobby, and although he reduced a few hours a week over the decades, Donnie has donned his work uniform. and went to the garage every day, five or six days a week, to tinker with this or that.

A classic Maine son, he was a man of few words and known for his kindness, patience, fairness and very dry sense of humor.

Donnie is survived by Lynne Chandler of Fryeburg, Sue Chandler of Westwood, Mass., her sister Mary Alice (Chandler) Clark and her husband Jim of New Gloucester, and their children Chandler, Beth, Jenn and Alicia.

Memorial donations may be made to Owl’s Head Transportation Museum (www.owlshead.org), DOVE (Domestic Violence Ended) (www.dovema.org) in Quincy, Mass., Maine Parkinson’s Society (https://maineparkinsonsociety.org/ ) , or the philanthropy of your choice.

A private burial was held at Lower (New) Gloucester Cemetery on June 20.

A memorial celebration of Donnie’s life will be held on Sunday, July 10 at 2 p.m. at the Old Saco Inn & Bistro (125 Old Saco Lane, www.oldsacoinn.com) in Fryeburg. Friends are invited to attend and encouraged to wear Oliver or vintage tractor t-shirts; John Deere will be frowned upon.

]]>
Where wild morels grow / c/o now https://cwinapp.com/where-wild-morels-grow-c-o-now/ Wed, 22 Jun 2022 07:00:00 +0000 https://cwinapp.com/where-wild-morels-grow-c-o-now/ Where wild morels grow / c/o now © Zara Pfeifer + 47 To share To share Facebook Twitter Mail pinterest WhatsApp Or https://www.archdaily.com/984031/where-the-wild-morels-grow-house-co-now © Zara Pfeifer Text description provided by the architects. Berlin’s real estate market has changed since the last move. It is no longer possible to find affordable apartments with extra space for […]]]>

Where wild morels grow / c/o now

Where the Wild Morels Grow House / c/o now - Exterior Photography, Facade, WindowsWhere wild morels grow / c/o now - Outdoor photography, FacadeWhere the Wild Morels Grow House / c/o now - Interior Photography, Facade, Beam, Windows, Garden, Yard, PatioWhere the Wild Morels Grow House / c/o now - Interior Photography, Facade, Garden, Yard, Beam+ 47